• br Methods br Results and discussion br

  2022-04-08

  

  Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian 1-Azakenpaullone as far

• Glucagon was described as an insulin secretagogue as early

  2022-04-08

  

  Glucagon was described as an insulin secretagogue as early as 1965 (Samols et al., 1965). Our studies extend these findings by demonstrating that this is a direct effect mediated by distinct receptors in the mouse pancreas. Previous experiments on isolated β Fmoc-D-Lys(Boc)-OH synthesis clearly sho

• br Materials and methods br Results br Discussion Present

  2022-04-08

  

  Materials and methods Results Discussion Present study demonstrated the ability of a GIP agonist, D-Ala2GIP, to protect against the QA-induced neurobehavioral phenotype of HD in rats, for the first time. D-Ala2GIP treatment significantly improved the behavioral deficits, biochemical and neu

• In single channel studies Zn

  2022-04-07

  

  In single channel studies, Zn2+ primarily inhibits GABA-A receptors through the reduction of channel opening probability (Smart, 1992, Smart et al., 1994). In slice recordings, Zn2+ significantly reduces phasic mIPSC event amplitude and kinetics, as well as desensitization kinetics (Barberis et al.,

• This study introduces a mouse model carrying the point

  2022-04-07

  

  This study introduces a mouse model carrying the point mutation R258W in Ffar1, which abolishes the stimulation of insulin secretion in response to long chain fatty acids. The minimal genetic alteration mirrors the human situation and has the advantage over conventional knockout/congenic mouse model

• fk506 br STAR Methods br Acknowledgments We thank the

  2022-04-07

  

  STAR★Methods Acknowledgments We thank the Shanghai Synchrotron Radiation Facility (SSRF) BL18U for help with X-ray data collection. We thank Dr. Thomas F.J. Martin for providing the pcDNA3.1-CAPS-1 plasmid and Dr. Xiaofei Yang for providing the pFHUUIG_shortU6 (l309) plasmid. We thank Dr. Shun

• Although oxidative stress induces a

  2022-04-07

  

  Although oxidative stress induces a decrease in intracellular ATP level, the underlying mechanism is obscured. We hypothesized that oxidative stress induced by H2O2 could decrease astrocytes ATP level through lysosome exocytosis in Ca2+-dependent pattern. In present study, using H2O2 stimulation to

• br Results and discussion Computer

  2022-04-07

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as bms 5 45 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety is found in various

• This crosstalk may be responsible for

  2022-04-07

  

  This crosstalk may be responsible for the beneficial effects of histamine H2 receptor inverse agonists on Siponimod mg pathologies and may also explain unwanted effects of these drugs on other tissues. In this way, Allen et al. reported an anaphylactoid reaction following cessation of high-dose rani

• MST are involved in signalling pathways following

  2022-04-07

  

  MST1/2 are involved in signalling pathways following along the canonical and noncanonical Hippo pathway. The canonical pathway is highly conserved between D. melanogaster and mammals and a master regulator of tissue growth. During development and within the canonical pathway, MST1/2 seem to have red

• Introduction As a compound class

  2022-04-07

  

  Introduction As a compound class, histone deacetylase inhibitors (HDIs) have been remarkably successful in the treatment of T-cell lymphoma [1]. Vorinostat (suberanilohydroxamic Cefepime Dihydrochloride Monohydrate or SAHA) was approved by the FDA in 2006 for the treatment of cutaneous T-cell lymp

• br Conclusion The addition of cellulose to natural substrate

  2022-04-07

  

  Conclusion The addition of 3CAI to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds while the in

• The use of antiinflammatory agents has been suggested as

  2022-04-06

  

  The use of antiinflammatory agents has been suggested as a potential treatment in HF. One strategy targeted tumor necrosis factor (TNF) in HF,, but the negative results of the clinical trials have been discouraging., Other clinical trials have attempted to suppress proinflammatory cytokine product

• In three independent groups identified GPR A HM

  2022-04-06

  

  In 2003, three independent groups identified GPR109A (HM74A) and GPR109B (HM74), two GPCRs, as the receptors for niacin., , GPR109A, which is present in all species, is a high affinity receptor for niacin., GPR109B, which is only present in human and chimpanzee, is a low affinity receptor for niac

• br Significant efforts are currently focused on

  2022-04-06

  

  Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) 327 2 synthesis hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-containing

15442 records 440/1030 page Previous Next First page 上5页 436437438439440 下5页 Last page