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Although unexpected based on our
2022-01-28
Although unexpected based on our predictions, low baseline and post-stress cortisol being associated with high anxiety has been previously documented in both clinical and healthy populations of humans (Beaton et al., 2006; Jezova et al., 2004; Shirotsuki et al., 2009; Vingerhoets et al., 1996), and
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Interestingly evidence has emerged recently
2022-01-28
Interestingly, evidence has emerged recently that suggests noncanonical roles of EZH2 in various cancers. For example, in addition to histone H3, EZH2 has been shown to methylate non-histone substrates, such as Jarid2 and STAT3, to regulate their transcriptional activities (He et al., 2012, Sanulli
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3-bromo-5-phenyl Salicylic Acid br Author contributions br A
2022-01-28
Author contributions Acknowledgements The work was financially supported by a grant from the Investigator-Initiated Studies Program (Ref. #38124) from Merck Sharp & Dohme, and, in part, from Research Grants Council of the Hong Kong Special Administrative Region, China (Ref. No.: 14110314), awa
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The first hypothesis better fertility in heifers that
2022-01-28
The first hypothesis, better fertility in heifers that had CL at day 0, was clearly supported by our results. Heifers with a CL had over 60% P/AI compared to ∼50% in heifers without CL. These results are consistent with several other studies reporting that cycling heifers have greater fertility than
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br Material and methods br Results br Discussion Organisms h
2022-01-28
Material and methods Results Discussion Organisms have developed a variety of anti-glycation defense mechanisms. In atm kinase inhibitor to the aldose-reductase-pathway or 2-oxoaldehyde dehydrogenase-pathway, the glyoxalase system is the only mechanism, which is not restricted to liver [19
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To further investigate its role
2022-01-28
To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that 5 alpha reductase inhibitor level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpr
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A major hurdle in purifying a membrane
2022-01-28
A major hurdle in purifying a membrane protein is finding a detergent that can preserve the protein, after releasing it from a given membrane, in a stable and non-aggregated state during purification steps [18,50]. The ability of various detergents used to solubilize and purify membrane proteins has
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Transcriptional translational modulators The discovery that
2022-01-28
Transcriptional/translational modulators. The discovery that β-lactam antibiotics like ceftriaxone enhance the in vivo expression of EAAT2/GLT-1 [31] has pioneered a completely new approach to EAAT modulation, with several additional EAAT activators following in its trail (Figure 2b) [32, 33, 34•, 3
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To get a broader view of
2022-01-28
To get a broader view of the interplay between glycolysis and Hippo signaling, we tested the involvement of YAP1 in the regulation of C-MYC and GLUT1 expression. We were able to detect a YAP1-TEAD1 interaction in the nuclear fraction of Jurkat LY2603618 and confirm the inhibition of this interactio
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CBR-5884 Solid tumors usually present insufficient supply of
2022-01-28
Solid tumors usually present insufficient supply of oxygen, activating the hypoxia inducible factor-1 (HIF-1) pathway, which prompts an adaptive response on genes that regulate glycolytic metabolism, promoting glucose uptake through the transcription of GLUTs [54]. Increasing evidence indicates that
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br Material and methods br Results br
2022-01-27
Material and methods Results Discussion Accumulating evidence suggests that the hippocampus is sensitive to noise-induced hearing loss and other forms of sensory deprivation, which deprives the hippocampus of sensory information required for its normal operations such as spatial navigation
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To synthesize the azaindole based
2022-01-27
To synthesize the 7-azaindole based compound , Suzuki coupling of 6-chloro-7-azaindole with 4-CFO-phenylboronic ICI 118,551 hydrochloride was carried out in the presence of Pd(dppf)Cl·CHCl to supply biaryl in quantitative yield (). Iodination at the C-3 position resulted 3-iodo-7-azaindazole . Al
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Methods br Results br Discussion In this report the
2022-01-27
Methods Results Discussion In this report, the therapeutic effect of a GCGR antagonistic antibody REMD2.59 was tested in 2 mechanistically divergent disease models of heart failure without confounding defects in global metabolism. Based on histological and functional analyses in both MI-injur
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br Acknowledgments The authors would like to
2022-01-27
Acknowledgments The authors would like to thank principal investigator Edward John Pratt, MD (Lilly-NUS Centre for Clinical Pharmacology, Singapore) and study investigator Martha Hernandez-Illas MD (QPS-MRA) along with site staff, and trial participants and their families. We thank Zvonko Milicev
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Recently a lot of synthetic FFA
2022-01-27
Recently, a lot of synthetic FFA1 agonists containing acidic moieties have been reported (Fig. 1) [13], [14], [15], [16], [17], [18], [19], [20], [21]. Notably, most of FFA1 agonists usually have the common biphenyl scaffold, which resulted in a relative deprivation in structure types of agonists [2
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