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There are numerous theories of schizophrenia etiopathology a
2021-07-19
There are numerous theories of schizophrenia etiopathology and genetics is often taken into consideration [25]. The dopamine D2 receptor is important since it is blocked by typical antipsychotic drugs with high affinity which is correlated with the ability to control psychotic symptoms in schizophre
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methylergometrine br Materials and methods br Results br
2021-07-19
Materials and methods Results Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive. In this study, we present evidence sh
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Previous studies reported that combined administration of
2021-07-19
Previous studies reported that combined administration of licorice/GL and TWHF/TP showed reduced toxicity and equal or even potentiated therapeutic efficacy when treating arthritis (YS et al., 2006, YS et al., 2008, Zhang et al., 2007). Our findings that GL reduced exposure to TP in rats confirmed t
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The consistent anti anxiety effects obtained with intra mPFC
2021-07-19
The consistent anti-anxiety effects obtained with intra-mPFC injections of CP 376395 strongly suggest a tonic role of CRF at CRF1 receptors located within this limbic TCS 359 area in the modulation of anxiety in the mouse on the EPM. Intra-mPFC injection of CP 376395 led mice to explore the potenti
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Moreover as shown in Fig f while the knockdown of
2021-07-19
Moreover, as shown in Fig. 5f, while the knockdown of SMURF2 in wild-type Doxorubicin has no significant effect on HSP27, in CK2α/α′(−/−) cells it leads to an increase of HSP27 level. These results suggest that SMURF2 affects HSP27 protein stability only when overexpressed, at least in our cell mod
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The repeat sequence TTAGGG of telomere
2021-07-19
The repeat sequence “TTAGGG” of telomere could be directly recognized by TERF1. TERF1 is indispensable for the maintenance of telomere Fluorouracil structure and integrity (Tan et al., 2017). Trf1 genetic depletion in vivo induces a persistent DNA damage response and telomere uncapping, which effec
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br Materials and methods br Results br Discussion Inflammato
2021-07-19
Materials and methods Results Discussion Inflammatory signalling and in particular the arachidonic Chlorprothixene cascade have been suggested as targets for disease modification, optimization of the therapeutic response, and even restoration of pharmacosensitivity (Potschka, 2010). Recent
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br Materials and methods Details on materials and methods ca
2021-07-17
Materials and methods Details on materials and methods can be found in the Supplemental material section. Results Discussion In our experiments we mimicked inflammation by LPS challenge of M0 macrophages. We discovered a strong increase in expression of CH25H and CYP7B1 while CYP27A1 and H
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CJ-42794 Mutation in BRCT II domain W R either
2021-07-17
Mutation in BRCT-II domain (W893R) either in the full-length context or the C-terminal context greatly reduced the expression of LIG4 (Fig. 2B, Fig. 3B), suggesting the importance of BRCT-II domain in the maintenance of LIG4. In this regard, it might be noted that LIG4 protein was undetectable in Li
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Diacylglycerol kinase was one of the hits
2021-07-17
Diacylglycerol kinase was one of the hits identified from the RNAi screen. Diacylglycerol kinases are conserved across a SCF, murine recombinant protein of species with more complex, multicellular organisms possessing several DGKs with differing protein domains, expression patterns and functions [61
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Moreover maintaining the pyrimidine pool is not the only
2021-07-17
Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s
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br Results br Discussion The sequence homology based cluster
2021-07-17
Results Discussion The sequence homology-based clustering of the human kinome by Manning et al. (2002) has been extremely useful to organize kinases into hepititis b by sequence relationship. Since kinases are such prominent drug targets, we expect that clustering of the kinases by their inhi
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br Fragment based drug discovery
2021-07-17
Fragment-based drug discovery (FBDD) is a powerful method to discover drug leads and has been widely adopted in both academia and industry. FBDD can be used to explore chemical calcitriol hormone space with libraries which are smaller in size, producing drug leads with high ligand-binding efficie
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CYP A is involved in the enzymatic
2021-07-17
CYP3A is involved in the enzymatic Etravirine australia of many therapeutic agents [29]. The activity of BFCOD has been used to monitor CYP3A activity in humans [30], pigs [31], mice [32], and fish [23]. The predominant isoform expressed in the human liver is CYP3A4 [33]. In pigs, CYP3A29 contribut
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Acknowledgments br Introduction Various researches have been
2021-07-17
Acknowledgments Introduction Various researches have been made in the field of the treatment of cancer and inflammatory diseases. Different mechanisms are involved in the progression of cellular damage that gives an idea about new drug targets. There are always some efforts to improve efficacy,
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