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Obviously there are some limitations in our study due
2021-01-28
Obviously, there are some limitations in our study; due to sample constraints, we had to focus our efforts on one specific T cell epitope from one candidate autoantigen. Optimally, we could have studied several different peptides in parallel. Additionally, all RA patients included in the study have
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In the previous study glutamyl endopeptidase
2021-01-28
In the previous study glutamyl endopeptidase of B. intermedius has been reported to be distributed in the j9 of B. intermedius as follows: 90% of synthesized enzyme has been detected in the culture liquid, 9.3% of glutamyl endopeptidase—in the fraction of membrane proteins [20]. The distribution of
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What are the molecular signals that
2021-01-28
What are the molecular signals that guide Tfh cells as they navigate around the lymph node in the course of the immune response? It was recently reported that Tfh cells inside GCs have high expression of SIPR2, which acts to repel them from the S1P-rich lymph in the SCS and promote their retention i
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Pyruvate dehydrogenase multienzyme complex PDHc catalyzes th
2021-01-28
Pyruvate dehydrogenase multienzyme complex (PDHc) catalyzes the oxidative decarboxylation of pyruvate, and subsequently acetylates coenzyme A (CoA) to acetyl-CoA during the tricarboxylic MK-5172 metabolic pathway using thiamine diphosphate (ThDP) and Mg2+ as cofactors. PDHc poses a key role in cyan
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In order to gain further insights into the
2021-01-28
In order to gain further insights into the role of peptidases in B. xylophilus, four cysteine proteases highly secreted by B. xylophilus (Cardoso et al., 2016) were selected four further characterisation. Materials and methods Results and discussion Structural prediction and analysis The i
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Besides the enhanced expression of costimulatory and adhesio
2021-01-27
Besides the enhanced expression of costimulatory and adhesion proteins, also the expression of the CD83 surface molecule is strongly enhanced during DC maturation (Banchereau and Steinman 1998; Banchereau et al. 2000). In fact, CD83 is a major cell surface marker for fully mature DC, as it can not b
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br Experimental br Declaration of interest
2021-01-27
Experimental Declaration of interest Introduction Material and methods Results and discussion Conclusion By screening the NMR Alisol A library an initial hit was found for an inhibitor of the PPI between the α-β subunits of CK2 with an IC50 of 900 μM. This compound was modified an
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We obtained two bands in RT
2021-01-27
We obtained two bands in RT-PCR for detection of SERPIN1-FOSB fusion when Taq DNA polymerase was used (Fig. 3A). Genuine RT-PCR product of SERPIN1-FOSB fusion was proved to be the shorter one (733 CHIR-090 pairs) by sequencing, and the longer band (863 base pairs) was shown to be derived from nativ
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p and p which are downstream of pAkt and pERK
2021-01-27
p21 and p16, which are downstream of pAkt and pERK1/2, are tumor suppressors which induce cell senescence and ppy synthesis arrest [[56], [57], [58]]. Inhibitors of pAkt or pERK1/2 can activate p21 and p16 and promote cell senescence and cell cycle arrest [11,12,[59], [60], [61]]. It is well known
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7026 br Epac in cardiovascular pathophysiology Epac orchestr
2021-01-27
Epac in cardiovascular pathophysiology Epac orchestrates signaling actors that regulate fundamental cellular functions and general biological effects. However, some important gaps still remain in the knowledge of the physiopathological role of Epac in the heart. So far, Epac has been implicated i
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We next turned our attention to the
2021-01-27
We next turned our attention to the 6-position of the indole (). It was found that the chlorine atom present in was extremely important. The des-chloro analogue showed nearly 30-fold less affinity for the EP receptor in the binding assay and was nearly 30-fold lower in activity in the functional ass
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br Acknowledgements The present study was
2021-01-27
Acknowledgements The present study was supported by the Medical Science and Technology Program of Zhejiang Province2014KYA228 (Zhijun Zhou), 2016KYA195 (Jie Li) and 2017KY714 (Qingqing Xia); Zhejiang Provincial Natural Science Foundation of ChinaQ17H120001 (Jie Li); and Scientific Research Projec
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br Results br Discussion The
2021-01-27
Results Discussion The process by which MBCs differentiate from GC B cell precursors remains mostly uncharacterized, in large part because of the uncertainty surrounding the nature of the precursor SGC 0946 sale within the GC. The identification here of a distinct subset of GC B cells, CCR6+
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Salicylic acid The roles of ginsenoside in E and S
2021-01-27
The roles of ginsenoside in E1 and 26S proteasome inhibition are shown in Table 2. The nitro substitute on the furan ring may be important for PYR-41 inhibition of the E1 enzyme (Yang et al., 2007). The macrocycle core and aliphatic tail of Largazole are responsible for inhibiting E1 activity (Unger
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Materials and methods Between January and December patients
2021-01-27
Materials and methods Between January 2006 and December 2008, 34 patients with GBM were treated with postoperative three-dimensional (3D) radiotherapy at Tartu University Hospital or North Estonian Medical Centre. Characteristics of patients are listed in Table 1. Results Discussion Radiothe
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