• The class C receptors also share a common agonist binding

  2025-01-17

  

  The class C receptors also share a common agonist-binding mode. In all cases, an agonist induces VFT closure by forming intermolecular bonds with surface residues in both the LB1 and LB2 domains (Geng et al., 2013, Geng et al., 2016, Kunishima et al., 2000, Muto et al., 2007, Nuemket et al., 2017, T

• From an historical perspective ligands for

  2025-01-17

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, fluvoxamine or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous ligands wer

• It is now well established that the cumulative

  2025-01-17

  

  It is now well established that the cumulative exposure to endogenous estrogens throughout a woman's life, mainly due to her reproductive history, has an impact on the risk of hormone-dependent breast cancer (Lambertini et al., 2016). Prolonged exposure to estrogens in the case of early age at menar

• br Author contribution br Acknowledgement br

  2025-01-17

  

  Author contribution Acknowledgement Introduction Since the initial finding of Gould et al. [1], showing the loss of dendritic spines in the hippocampus after ovariectomy and its rescue after treatment of the animals with estradiol, a tremendous number of studies have demonstrated a role of

• In order to determine whether the faster Rh induced apoptosi

  2025-01-17

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in Moniliformin sodium salt depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, i

• Furthermore because most of foods and beverages have been co

  2025-01-16

  

  Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w

• br Eprosartan The AT R antagonist

  2025-01-16

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Nicotinamide and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events, i

• AT7519 Hydrochloride br Acknowledgements This work was suppo

  2025-01-16

  

  Acknowledgements This work was supported by National Natural Science Foundation of China (Nos. 21376172, 21528601 and 21621004) and the Natural Science Foundation of Tianjin from Tianjin Municipal Science and Technology Commission (Contract No. 16JCZDJC32300). Introduction Alzheimer’s disease

• MT SGL encourages a individual feature selection based on th

  2025-01-16

  

  MT-SGL encourages (a) individual feature selection based on the utility of the features across all tasks with ℓ2,1-norm and (b) task specific group selection based on the utility of the group with G2,1-norm, i.e., Epothilone D regions of interest (ROI) for that task. Unlike basic SGL for regression

• br ABCA and cancer drug response Overall the expression of

  2025-01-16

  

  ABCA2 and cancer drug response Overall, the expression of ABC transporters has been linked with multidrug resistance phenotypes through the efflux of drugs via ATP-dependent transport. For example, 13 distinct transporters (ABCA2, ABCB1, ABCB4, ABCB11, ABCC1–6 ABCC10, ABCC11 and ABCG2) have been

• Glucose permeability studies demonstrated a

  2025-01-16

  

  Glucose permeability studies demonstrated a high glucose flux through the SF films used in the present work. Recent diffusion studies, including small molecular drugs and oxygen permeation through SF membranes [32], further support the quality of SF and its possible application as a material for bio

• br New AMPK activators Fenofibrate is a

  2025-01-16

  

  New AMPK activators Fenofibrate is a drug of the fibrate class used for the treatment of dyslipidemia [53] but is also an agent that could alleviate DN-induced alterations through AMPK activation (Fig. 2). Streptozotocin-induced diabetic rats treated with fenofibrate improved in not only renal fu

• The specific binding domain between

  2025-01-16

  

  The specific binding domain between PGK in group B strepotocci (GBS) and actin had been reported . PGK as the actin-binding protein identified in TMW 1.1434, which displayed highly significant adhesion was investigated for the binding sites and compared to bacteria with less strong adhesion to acti

• We have expressed the ECDs of the human

  2025-01-16

  

  We have expressed the ECDs of the human α1, β1, γ and ɛ AChR subunits in the past using the methylotropic yeast Pichia pastoris as soluble glycosylated proteins [15], [16]. Further work with the γ subunit ECD revealed a marked improvement of the solubility and yield following the mutation of hydroph

• In order to increase the oral bioavailability abiraterone is

  2025-01-16

  

  In order to increase the oral bioavailability, abiraterone (157) is being used in the form of its 3β-acetoxy prodrug, abiraterone acetate (156). In spite of the fact that high-fat meals increase the oral Tumor growth inhibition of abiraterone acetate (156), it is recommended that this drug should b

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