• br Materials and methods Male Sprague Dawley

  2022-01-17

  

  Materials and methods Male Sprague–Dawley rats (Faculty of Pharmacy, Pharos University, Alexandria, Egypt) weighing 180 to 200g were used in this study. All experiments were performed in strict accordance with institutional animal care and use guidelines. Results Discussion The current stu

• Here we report the genomic structure and

  2022-01-17

  

  Here we report the genomic structure and the phylogenetic analysis of testis-specific Ser/Thr kinase haspin gene. Materials and methods Results Discussion The isolation and analysis of haspin genomic DNA showed that haspin was an intron-less gene and localized in an intron of integrin αM29

• Our data indicate that curcumin reduced MDA

  2022-01-17

  

  Our data indicate that curcumin reduced MDA and LOOH formation in plasma and kidney induced by gentamicin treatment. The results demonstrate the protective effect of this compound against oxidative damage to these membranes. Moreover, the ability of curcumin to reduce the formation of LOOH induced b

• Membrane based integrative treatment processes emerge as pot

  2022-01-17

  

  Membrane based integrative treatment processes emerge as potential solution compared to the conventional techniques. Gisi et al. (2009) presented a treatment scheme for tannery wastewater consisting of a biological pre-treatment and then a polymer as coagulant followed by reverse GLP-2 (rat) with a

• The number of small molecule GSK inhibitors

  2022-01-17

  

  The number of small molecule GSK-3 inhibitors is continuously rising and many have been tested in animals. These studies have provided additional support for specific roles of GSK-3 in neuronal functions under both normal and pathological conditions. Inhibition of GSK-3 has profound effect on neurop

• (S)-AMPA mg Recently a G protein coupled receptor GPR a was

  2022-01-17

  

  Recently, a G-protein-coupled receptor, GPR109a, was identified as a molecular target for niacin. Mechanistic studies have suggested that the benefits of niacin therapy may result from the activation of GPR109a located on adipocytes. Recent experiments have shown that niacin activation of GPR109a re

• br Conflict of interest statement

  2022-01-17

  

  Conflict of interest statement Acknowledgements We acknowledge the support of Zoetis Animal Health, Estrotect, Select Sires and Texas A&M AgriLife Research. The assistance of Randle Franke and Ernest Soto is also gratefully acknowledged. Background Luteal phase deficiency (LPD) is caused b

• FFAR is highly expressed not only in cells but

  2022-01-17

  

  FFAR1 is highly expressed not only in β cells but also in α carboxypeptidase a (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with the many ot

• The monomer composition and the variation

  2022-01-17

  

  The monomer composition and the variation in the cryogelation process can result in cryogels with slightly different properties. The adequate characterization of these matrices is advisable in the studies aiming a better understanding of flow inside its structure and also the interactions between th

• br Acknowledgements This work was supported by a fellowship

  2022-01-17

  

  Acknowledgements This work was supported by a fellowship to C.H. under the ‘100 Foreign Expert’ scheme of the Shanxi province government(R100456). Conflict of interest: Dr. Holscher is a named inventor on a patent submitted by Lancaster University on the use of dual GLP-1/GIP analogues in neurode

• br Discussion br Concluding remarks There are potentially

  2022-01-17

  

  Discussion Concluding remarks There are potentially hundreds or thousands of G-quadruplexes which form within promoters, telomeres, RNA transcripts, and even LINEs and SINES [9,11,121,122]. As articulated previously [27], G-quadruplexes are easily targetable with heterocyclic aromatic compound

• Focal adhesion kinase FAK is a non

  2022-01-15

  

  Focal adhesion kinase (FAK) is a non-receptor type tyrosine kinase that can further cooperatively interact with receptor tyrosine kinase signaling to regulate adhesion, migration, survival, proliferation, polarization, and differentiation [12]. Following activation, phosphorylated extracellular regu

• The CRY protein contains a conserved photolyase

  2022-01-15

  

  The CRY1 protein contains a conserved photolyase homology region crucially involved in repression of CLOCK/BMAL1; a C-terminal helix also known as the predicted coiled coil (CC), which interacts with PER2 and FBXL3 in a mutually exclusive manner; and a C-terminal extension also referred to as the “t

• Most hexokinases are widely expressed but distinct hexokinas

  2022-01-15

  

  Most hexokinases are widely expressed but distinct hexokinases predominate specific tissues (Katzen and Schimke, 1965, Rogers et al., 1975). Hexokinase I is found in all mammalian tissues, but is most abundant in the α-mangostin and kidney (griffin et al., 1992). Hexokinase II is the primary hexoki

• Substrate affinity and specificity can be enhanced by dockin

  2022-01-15

  

  Substrate affinity and specificity can be enhanced by docking interactions, in which regions distal to the site of NSC23766 bind to grooves, pockets, or surfaces outside of the kinase catalytic cleft 1, 2, 5, 6. Like catalytic site interactions, docking interactions can involve recognition of short

14743 records 439/983 page Previous Next First page 上5页 436437438439440 下5页 Last page