• In a previous study we reported that

  2021-05-24

  

  In a previous study we reported that the systemic administration of the α1-adrenergic receptor antagonist prazosin attenuates the deficit in Fmoc-Ala-OMe reward function associated with precipitated nicotine withdrawal (Bruijnzeel et al., 2010). One of the aims of the present experiments was to inv

• br Materials and methods br Results and discussion br

  2021-05-22

  

  Materials and methods Results and discussion Conclusions Acknowledgements This work was supported financially by the LIAONING S&T Project (No. 20180550107) and Basic Scientific Research Funds of DLNU (0918110143). Introduction Since 1970s, numerous artificial mimetic enzymes have bee

• br Materials and methods br Result and

  2021-05-22

  

  Materials and methods Result and discussion qRT-PCR was utilized to explore the effect of acetamizuril on the mRNA level of enolase. The results were analyzed according to the Livak 2−ΔΔCT method (Schmittgen and Livak, 2008): the mean CT of the enolase in treated and untreated samples was 29.8

• CYP contributes to the metabolism of more than of currently

  2021-05-22

  

  CYP450 contributes to the metabolism of more than 90% of currently available drugs (Shapiro and Shear, 2002). Currently, CYP1A is the most studied xenobiotic-metabolizing isoform in fish and is often used as a biomarker for early effects of pollutants in aquatic organisms (Havelkova et al., 2007). T

• br Discussion The regulation of intracellular

  2021-05-22

  

  Discussion The regulation of intracellular cholesterol levels is a biological process of vital importance for cellular function and integrity, and involves robust transcriptional and post-transcriptional mechanisms that are sensitive to metabolic feedback control. Amongst post-transcriptional mec

• KT 5720 synthesis br Results and Discussion br Conclusions U

  2021-05-22

  

  Results and Discussion Conclusions Understanding the connections between function and fitness is a primary goal of many biological disciplines including systems biology and molecular evolution. While sound approaches have been developed to understand the connections between function and fitnes

• BMS-345541 br Significance Dysregulation of dopamine homeost

  2021-05-22

  

  Significance Dysregulation of dopamine homeostasis contributes to Parkinson's disease (PD). The nuclear receptor Nurr1 plays a central role in dopamine homeostasis, regulating the transcription of BMS-345541 governing the synthesis, packaging, and reuptake of dopamine. Efforts to capitalize on N

• Verapamil a calcium channel blocker used clinically as a cor

  2021-05-22

  

  Verapamil, a calcium channel blocker used clinically as a coronary vasodilator, was amongst the first compounds identified that could reverse MDR and potentiate the effects of MDR1 substrates such as vincristine [15], [16]. Verapamil, along with a number of other MDR1 blockers, have proved largely u

• br Experimental Procedures br Acknowledgments The authors wi

  2021-05-22

  

  Experimental Procedures Acknowledgments The authors wish to thank P. Costet (University of Bordeaux) and Véronique Guyonnet-Duperat (FR TransBioMed, Plateforme de Vectorologie, University of Bordeaux) and Prof. Nils-Göran Larsson and Dr. Bettina Bertalan (Max Planck Institute for Biology of Ag

• hdac inhibitor br NADH and NADPH Turnover and the Putative

  2021-05-22

  

  NADH and NADPH Turnover and the Putative Role of Alternative NAD(P)H Dehydrogenases Still very little is known about the metabolic function of external and internal alternative NADH:UQ oxidoreductases, and almost nothing is known about the mechanisms underlying their metabolic regulation, especia

• A range of therapies exists for the treatment of

  2021-05-22

  

  A range of therapies exists for the treatment of inflammation-driven diseases, which can be summarized as non-steroidal anti-inflammatory drugs (NSAIDs), corticoids and steroidal-related drugs (Ward et al., 2008). Despite of these notable successes, there are still major unmet medical needs in the t

• Autophagy Compound Library br Conflict of interest br Acknow

  2021-05-22

  

  Conflict of interest Acknowledgments Dr. Hauger was supported by a BLR&D Merit Review grant from the Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development. Dr. Hauger also received support from the VA Center of Excellence for Stress and Mental Healt

• AY 9944 dihydrochloride In contrast to PEGylated proteins wh

  2021-05-22

  

  In contrast to PEGylated proteins which tend to have reduced AY 9944 dihydrochloride in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the

• The CPA parameters of SO

  2021-05-22

  

  The CPA parameters of SO2 were calculated based on Eq. (11) using the vapor pressure and saturated liquid density data of SO2 over the reduced temperature range of 0.55 to 0.9. All of the data used were taken from the NIST database [53]. The resulting CPA parameters of SO2 are presented in Table S1

• The dermal ECM also shows specificities During zebrafish emb

  2021-05-21

  

  The dermal ECM also shows specificities. During zebrafish embryogenesis, the epidermis is composed of the outer periderm and the inner basal keratinocytes, which are responsible for the initial deposition of ECM in the primitive acellular dermis [17].The dermal endothelial cells, a species-specific

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