• br Conclusion In this study we have

  2019-08-15

  

  Conclusion In this study, we have shown the construction, expression and purification of CPG2 fused to the HIV-1 TAT peptide (TAT–CPG2). We have demonstrated for the first time that TAT-CPG2 in both native and denatured forms could be efficiently transduced into the HepG2 cells. Also, we have pro

• As a co factor CIITA lacks the ability to recognize

  2019-08-15

  

  As a co-factor, CIITA lacks the ability to recognize and directly bind to specific DNA elements to regulate transcription; instead, it relies on interaction with sequence-specific transcription factors (TFs) to be recruited to the chromatin. Therefore, the observation that CIITA binds to a specific

• A prominent example of such enzyme is the proteasome

  2019-08-15

  

  A prominent example of such enzyme is the proteasome, a highly promising target not only in cancer, but also in inflammatory and autoimmune diseases. Circulating proteasomes and respective anti-proteasome autoantibodies were detected in serum samples from patients with autoimmune diseases such as mu

• px express in Once sufficient single stranded DNA ssDNA

  2019-08-15

  

  Once sufficient single-stranded DNA (ssDNA) has been exposed at origins, synthesis of leading and lagging strands is initiated by the DNA polymerase α-primase complex (Pol α). Lagging-strand synthesis requires repeated cycles of Pol α-dependent priming and subsequent primer extension by Pol δ. Pol α

• tbtu br Conclusion br Competing interests br Authors

  2019-08-15

  

  Conclusion Competing interests Authors\' contributions Acknowledgements The work was supported by Aurigene Discovery Technologies (M) Sdn. Bhd., Industrial Doctoral Program sponsorship by Ministry of Higher Education, Malaysia and research grants by the University of Malaya, grant number

• Panobinostat powder For the SAR optimization of the right ha

  2019-08-15

  

  For the SAR optimization of the right hand side, it was decided to explore the inclusion of the key carboxylic Panobinostat powder moiety present in the original DGAT-1 inhibitors from . Analogs were constructed by the synthetic routes outlined in , . In , the methylene-oxy linker was introduced by

• br Ubiquitin Capture by the Mobile APC RING

  2019-08-14

  

  Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the Cerulenin correlates with processivity o

• During the past three decades

  2019-08-14

  

  During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot

• br Material and methods br Results br Discussion Monomeric C

  2019-08-14

  

  Material and methods Results Discussion Monomeric CDK5 shows no enzymatic activity and requires the association with a regulatory partner for activation (Dhavan and Tsai, 2001). Here, we found that CDK7 might be one of the partners required for activation of CDK5 in the skin tissue, based o

• br Materials and methods br Results and discussion br Conclu

  2019-08-14

  

  Materials and methods Results and discussion Conclusions In this study, we have investigated the possibility that hierarchical phosphorylation by CK2 may play a role in cellular signal transduction. Hierarchical phosphorylation by CK2 requires multiple consensus determinants with specific s

• Water inorganic salts sugars lipids nucleic acids

  2019-08-14

  

  Water, inorganic salts, sugars, lipids, nucleic acids and proteins are the main basic materials forming the organism. Life activities can be controlled or regulated by a series of complicated and chain-reactive protein–protein interactions. Protein–protein interaction is considered as the bases and

• Two isoforms of intracellular ER

  2019-08-14

  

  Two isoforms of intracellular ER, ERα, and ERβ, after binding to estrogens and translocate to the nucleus, activate some transcription factors and signaling pathways. The deregulation of estrogenic pathways can elevate transcriptional activity contributed to the development of cancer. Expression of

• Constitutive activity of Ras Raf MEK ERK

  2019-08-14

  

  Constitutive activity of Ras/Raf/MEK/ERK pathway plays a critical role on melanoma growth, thus inhibition of activity of Ras, Raf and MEK can reduce ERK activity, leading to a decrease in melanoma cell proliferation, survival and invasion (Burotto et al., 2014; Paluncic et al., 2016). Our results a

• In studies directed toward the development of

  2019-08-14

  

  In studies directed toward the development of sequence-specific major-groove binding small alzheimer\'s association [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA bind

• Apelin-13 br Results and discussion To check the hypothesis

  2019-08-14

  

  Results and discussion To check the Apelin-13 that the charge of α-synuclein can be altered due to the glycation, we measured zeta potential of native α-synuclein and α-synuclein glycated by two different glycating agents, methylglyoxal (MG) and glyceraldehyde-3-phosphate (GA-3-P). The value for

15441 records 971/1030 page Previous Next First page 上5页 971972973974975 下5页 Last page