• It is established that hypoxia can induce autophagy

  2019-04-29

  

  It is established that hypoxia can induce autophagy [32,34–37]. We evidenced the autophagic activation in the cultured human osteosarcoma MG-63 carboxypeptidase after incubation in 1% O2 for 24h. The concomitantly elevated LC3 protein levels with HIF-1α high expression on OS tissue sections also in

• Loss of function mutations in

  2019-04-29

  

  Loss-of-function mutations in the INa channel α-subunit (SCN5A) is the most common (~20%) etiology of BrS [49]. Recently, SCN10A, a neuronal sodium channel gene encoding Nav1.8 has been identified as a major susceptibility gene (~16%) for BrS [50]. In addition, loss-of-function mutations in the ICa,

• Although SCN A variants account for of

  2019-04-29

  

  Although SCN5A variants account for 18–28% of BrS [196], SCN5A genetic testing is complicated by an approximately 3–5% “benign” variant frequency in the general population [194]. Therefore, even in the most common genetic cause of BrS, 1 in 10 “positive” tests could be a “false- positive” even if fo

• br Enterohepatic circulation of bile

  2019-04-29

  

  Enterohepatic circulation of bile acids during feeding The primary bile acids in humans, CA and CDCA, are synthesized from cholesterol by two biosynthetic pathways in liver hepatocytes. The “classic” or “neutral” pathway is the major pathway for the synthesis of bile acids in humans. This pathway

• We noted a significant increase of CI in the

  2019-04-29

  

  We noted a significant increase of 22% (95% CI 5–30) in the incidence of haemorrhagic stroke in low-income and middle-income countries in the past two decades, with a 19% (5–30) significant increase in people younger than 75 years. A non-significant increase of 6% (18%, −7 to 32) was shown in the in

• Obstetric fistula is a birth related

  2019-04-29

  

  Obstetric fistula is a birth-related pelvic injury resulting from prolonged and obstructed labour and is characterised by involuntary loss of urine, faecal matter, or both. Obstetric fistula affects more than 2 million women residing mainly in low-income countries located in sub-Saharan Africa and A

• br Algunas conclusiones y una agenda abierta

  2019-04-29

  

  Algunas conclusiones y una agenda abierta El populismo, como un modo de inclusión radical que pone en cuestión los límites de la comunidad, ha sido una clave interpretativa recurrente Wnt agonist 1 Supplier la vez que obliga a poner atención en el contenido de las articulaciones. Esto tiene dos e

• Por ltimo el tercer rasgo constitutivo es la relaci

  2019-04-29

  

  Por último, el tercer rasgo constitutivo es la “relación ficción/realidad”, ineludible al referirse al “valor de verdad [que se otorga en el pacto de lectura al enunciado testimonial”. Me temo que este aspecto podría escindirse en dos polémicas creadas en torno al género: la ficcionalización de la m

• br Methods br Results br Discussion This study

  2019-04-28

  

  Methods Results Discussion This study has provided preliminary knowledge to further explore the autonomic and the cardio-respiratory responses to exercise in the BrS patients. This knowledge can now be applied to further diagnosis and evaluation and to administer appropriate treatments. How

• Berlitch muestra c mo la negativa h ngara a las

  2019-04-28

  

  Berlitch muestra cómo la negativa húngara galanin las demandas de derechos colectivos ha llevado a que los movimientos nacionalistas de los pueblos sometidos terminaran en la ilegalidad y la persecución a manos de los supuestos revolucionarios. Asimismo, la negativa del Estado húngaro para pensarse

• br Bacterial glycoconjugate vaccines contain capsule derived

  2019-04-28

  

  Bacterial glycoconjugate vaccines contain capsule-derived bacterial polysaccharides chemically conjugated to carrier proteins and are highly immunogenic in the infant population for whom they were originally designed. This class of vaccine has shown a profound impact on the incidence of both invas

• Chronic hepatitis B virus HBV infection is prevalent

  2019-04-28

  

  Chronic hepititis b virus (HBV) infection is prevalent in many Asian countries, notwithstanding three decades of universal hepatitis B vaccination programs. The invention of nucleos(t)ide analogs (NUCs) was a breakthrough in the treatment of chronic hepatitis B (CHB). However, HBV continues to be a

• br Case At the time of

  2019-04-28

  

  Case At the time of admission, the patient\'s heart rate was irregular with an average rate of 76beats per minute (bpm) (Fig. 1). Her ECG showed sinus rhythm conducted with left-bundle branch block (LBBB) and associated with multiple ectopic premature ventricular beats (PVBs). The PVBs were relat

• This patient s shortest R

  2019-04-28

  

  This patient\'s shortest R–R interval on ECG was about 200ms (300bpm), which indicated high risk of sudden cardiac death. The patient underwent catheter ablation. ACC/AHA/ESC guidelines for the management of patients with supraventricular arrhythmias [1], which include accessory pathway-mediated arr

• In February a left neck infiltrating purpuric

  2019-04-28

  

  In February 2013, a left neck infiltrating purpuric lesion around a previous surgical scar (lymph node biopsy) with mild pain was noted. A subsequent skin biopsy revealed metastatic adenocarcinoma, compatible with ampulla of Vater primary, thereby confirming disease progression with skin metastasis.

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