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In the past three decades along with rapid economic
2019-04-30
In the past three decades, along with rapid economic growth in China, there has been a striking increase in alcohol consumption, greater than in most other parts of the world (). Although the orphan receptor drinking level in China used to be far lower than in many high-income and middle-income coun
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A Irmandade da Santa Casa de Miseric rdia de
2019-04-30
A Irmandade da Santa Casa de Misericórdia de São Paulo é formada por membros da sociedade que passam ionomycin ser chamados de Irmãos. Desses, são escolhidos os que compõem a Mesa Administrativa, a qual escolhe a diretoria, nomeados como provedor e superintendente. Em geral, são profissionais como
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A esta ambivalencia del narrador se debe que Tampico sea
2019-04-29
A esta ambivalencia del narrador, se debe que Tampico sea calificada como “una de las obras ejemplares del género” de la novela antiimperialista, en el esclarecedor estudio de Luis Alberto Sánchez, y esté situada entre muchas otras narraciones escritas por latinoamericanos. El crítico peruano vincul
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chir99021 manufacturer De esta forma siguiendo la multicitad
2019-04-29
De esta forma, siguiendo la multicitada metáfora de Hemingway, el relato policiaco es solamente la punta del iceberg, mientras que los excesos de la política se encuentran debajo del mar (de lama). El relato policíaco, entonces, no es sólo un “pretexto narrativo”, o una simple guía para el lector me
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br Introduction Percutaneous transcatheter device
2019-04-29
Introduction Percutaneous transcatheter device closure of atrial septal defects (ASD) has become an effective alternative therapy to surgical repair in patients with secundum type ASD. Amplatzer ASD or ventricular septal defect (VSD) occluders were used for the closure of ASDs or VSDs, respective
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The risk stratification of patients with ERS is
2019-04-29
The risk stratification of patients with ERS is even more confusing and further studies are required. As mentioned in the demographics, the traditional definition of ER emphasizes the presence of ST segment elevation, and the subjects with ER with this traditional concept do not have adverse outcome
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It is established that hypoxia can induce autophagy
2019-04-29
It is established that hypoxia can induce autophagy [32,34–37]. We evidenced the autophagic activation in the cultured human osteosarcoma MG-63 carboxypeptidase after incubation in 1% O2 for 24h. The concomitantly elevated LC3 protein levels with HIF-1α high expression on OS tissue sections also in
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Loss of function mutations in
2019-04-29
Loss-of-function mutations in the INa channel α-subunit (SCN5A) is the most common (~20%) etiology of BrS [49]. Recently, SCN10A, a neuronal sodium channel gene encoding Nav1.8 has been identified as a major susceptibility gene (~16%) for BrS [50]. In addition, loss-of-function mutations in the ICa,
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Although SCN A variants account for of
2019-04-29
Although SCN5A variants account for 18–28% of BrS [196], SCN5A genetic testing is complicated by an approximately 3–5% “benign” variant frequency in the general population [194]. Therefore, even in the most common genetic cause of BrS, 1 in 10 “positive” tests could be a “false- positive” even if fo
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br Enterohepatic circulation of bile
2019-04-29
Enterohepatic circulation of bile acids during feeding The primary bile acids in humans, CA and CDCA, are synthesized from cholesterol by two biosynthetic pathways in liver hepatocytes. The “classic” or “neutral” pathway is the major pathway for the synthesis of bile acids in humans. This pathway
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We noted a significant increase of CI in the
2019-04-29
We noted a significant increase of 22% (95% CI 5–30) in the incidence of haemorrhagic stroke in low-income and middle-income countries in the past two decades, with a 19% (5–30) significant increase in people younger than 75 years. A non-significant increase of 6% (18%, −7 to 32) was shown in the in
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Obstetric fistula is a birth related
2019-04-29
Obstetric fistula is a birth-related pelvic injury resulting from prolonged and obstructed labour and is characterised by involuntary loss of urine, faecal matter, or both. Obstetric fistula affects more than 2 million women residing mainly in low-income countries located in sub-Saharan Africa and A
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br Algunas conclusiones y una agenda abierta
2019-04-29
Algunas conclusiones y una agenda abierta El populismo, como un modo de inclusión radical que pone en cuestión los límites de la comunidad, ha sido una clave interpretativa recurrente Wnt agonist 1 Supplier la vez que obliga a poner atención en el contenido de las articulaciones. Esto tiene dos e
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Por ltimo el tercer rasgo constitutivo es la relaci
2019-04-29
Por último, el tercer rasgo constitutivo es la “relación ficción/realidad”, ineludible al referirse al “valor de verdad [que se otorga en el pacto de lectura al enunciado testimonial”. Me temo que este aspecto podría escindirse en dos polémicas creadas en torno al género: la ficcionalización de la m
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br Methods br Results br Discussion This study
2019-04-28
Methods Results Discussion This study has provided preliminary knowledge to further explore the autonomic and the cardio-respiratory responses to exercise in the BrS patients. This knowledge can now be applied to further diagnosis and evaluation and to administer appropriate treatments. How
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